CELLiST
Solution Center (CSC)

Service

CELLiST Solution Center (CSC)是位于Incheon Free Economic Zone我司研究设施,其核心作用是向需要使用我 司培养基的客户提供必要的培养基相关服务。

CSC的研究人员使用机器人培养基组成设备及自动化的超小型生物反应器分析系统,快速进行细胞/培养基开发研究。对通过培养过程获取的数据,利用最新的multi-omics分析工艺及专业化的big-data/AI分析工艺形成文件化。 除了使用最新设备和Ajinomoto(株)的高性能氨基酸以外,通过灵活自由的业务程序,解决客户的问题及根据客户的要求通过最少的时间进行应对也是CSC的优势之一。

Making your own media

with your cell line by using various media library

Schedule could be changeable according to development status Patent clearance for optimized formulation, manufacturing process development & transfer, determine quality spec, medium stability test, and so on will be carried out separately.

What We Can Offer

Customer Support, Consultation & Remote Services

Providing of media samples
Frequent support & rapid troubleshooting service on all cell culture, media or process issues Comprehensive Spent Media analysis service, including cell viability, IgG titer, full amino acid consumption profile and metabolites analysis

Cell Adaptation & Media Screening

Comprehensive adaptation procedure optimization @ CSC Lab
Media screening (using CELLiST media library as well as any desired formulations by the customer) Cell culture in either shake flasks or Ambr15® microbioreactor system Complete spent media analysis Cell stock production & validation

Scale-up Support

Close support to our customers through their process development and scale-up stages up to commercial manufacturing Application of quality by design (QbD) concepts and DoE approach for process & media development Scale-up tests in 3L bioreactors (in near future, till then can use nearby facilities)

Protein Quality Analysis

Accurate, rapid characterization of product CQAs using cutting-edge, high-throughput technology Complete Glycan profiling Charge variants analysis Optimization of media formulation and process parameters for the desired protein quality profile

Our Service Track Record

Stage R&D Clinical NDA Marketed
Pipelines 22 21 1 4

Daiichi Sankyo Co., Ltd.

Rapid analysis of a newly established CHO cell line was followed with intensive media development process, leading to significantly improved productivity in a short period of time.

Our unique capabilities allow for strong and flexible support to the customer:

Development can be quickly initiated with starting medium optimal for the customer's cell line. Candidate redia calbe rapidly evaluated by an array of industry-leading high throughput systems supported by experienced researchers, Complete, high-throughput analysis of spent media, including amino acids, vitamins, minerals and other components, allows for a customized and efficient optimization. DoE and statistical analysis, combined with our long experience in media formulation, leads to rapid design of optimal composition. Keeping in mind customer goals and deadlines. our professional development team supports the customer throughout the process up to commercialization stage.

Chugai Pharmaceutical Co., Ltd.

Efficient media development and optimization cycles throughout the collaboration with Chugai led to drastic increase in productivity, reaching high protein titer of 12 g/L. In the development process, our proprietary L-Cysteine technology, allowing high concentration and liquid stability, contributed to the largel improvement in titer. In addition, media performance was further enhanced based on in-house knowledge* and additional spent media analysis, optimizing concentrations of potassium and phosphate, among other components.

Our L-Cysteine technology

Precipitation Inhibition

Our proprietary composition stabilized liquid media enhancing L-Cysteine.

Titer Improvement

L-Oysteine high-concentration with liquid-stability increased liter.

Global CELLiST Solution Center (CSC)s

70, Songdogwahak-ro, Yeonsu-gu. Incheon, Republic of Korea
Tel:+-82-32-210-2695 Fax: +82-32-210-2607
Mail : yaron.silberberg.dk2@asv,ajinomoto.com
Ahmedabad, India
Mail : parshadg.hirapara.ut3@asv.ajinomoto.com
Shanghai, China
Mail : mingqi_fan@ajinomoto.com.cn
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